An oropharyngeal gonorrhoea controlled human infection model: a provisional protocol using a novel Neisseria gonorrhoeae challenge strain

Abstract

Introduction: Gonorrhoea is a sexually transmissable infection caused by Neisseria gonorrhoeae that causes a significant global burden of disease. Urogenital infection can result in long-term impacts on reproductive, perinatal, and neonatal health. Little progress has been made in the public health control of gonorrhoea, and novel preventative strategies are urgently needed. Furthermore, future gonorrhoea management is threatened by increasing antimicrobial resistance (AMR). Oropharyngeal gonorrhoea is usually asymptomatic; likely plays an important role in development of AMR; and is a high-risk site for treatment failure. Here, we describe a protocol for an oropharyngeal gonorrhoea controll..